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AboutPricing
Drug ReportsInsulin human
Humulin r u-100, Insuman(insulin human)
Afrezza, Humulin, Insuman, Myxredlin, Novolin (insulin human) is a protein pharmaceutical. Insulin human was first approved as Humulin r u-100 on 1982-10-28. It has been approved in Europe to treat diabetes mellitus.
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Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
Trade Name
FDA
EMA
Afrezza, Humulin u, Myxredlin, Novolin (discontinued: Humulin u)
Combinations
Humulin, Novolin
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Insulin human
Tradename
Proper name
Company
Number
Date
Products
Humulin R U-500insulin humanEli LillyN-18780 RX1994-03-31
2 products
Humulin R U-100insulin humanEli LillyN-18780 OTC1982-10-28
2 products
Afrezzainsulin humanMannkind CorporationN-22472 RX2014-06-27
3 products
Novolin Rinsulin humanNovo NordiskN-19938 OTC1991-06-25
2 products
Show 1 discontinued
Insulin human
+
Insulin isophane human
Tradename
Proper name
Company
Number
Date
Products
Humulin 70/30insulin isophane human and insulin humanEli LillyN-19717 OTC1989-04-25
3 products
Novolin 70/30insulin isophane human and insulin humanNovo NordiskN-19991 OTC1991-06-25
2 products
Insulin human
Tradename
Proper name
Company
Number
Date
Products
Myxredlininsulin human BaxterN-208157 RX2019-06-20
1 products
Labels
FDA
EMA
Brand Name
Status
Last Update
afrezzaBiologic Licensing Application2023-02-27
exubera2008-04-08
humalog 70/30New Drug Application2010-11-05
humulinBiologic Licensing Application2025-05-27
humulin humulin 70/30New Drug Application2013-12-18
humulin humulin nNew Drug Application2013-12-18
humulin humulin n sterile diluentNew Drug Application2013-11-14
humulin sterile diluentBiologic Licensing Application2023-03-07
humulin 70/302009-03-30
humulin humulinBiologic Licensing Application2024-12-10
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
7715 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes mellitusD003920EFO_0000400E08-E131512417779157588
Type 2 diabetes mellitusD003924EFO_0001360E11471612970143404
Type 1 diabetes mellitusD003922EFO_0001359E10699561775226
Drug delivery systemsD016503241613
HypoglycemiaD007003E16.232611
ObesityD009765EFO_0001073E66.912238
OverweightD050177E66.32114
HyperglycemiaD006943R73.91113
Insulin resistanceD007333EFO_0002614E88.819123
Body weight changesD001836112
Show 3 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
FibrosisD005355133
Cystic fibrosisD003550EFO_0000390E84133
SepsisD018805EFO_0001420A41.9112
Pituitary dwarfismD004393EFO_1001109E23.0112
DwarfismD004392E34.31112
Cardiovascular diseasesD002318EFO_0000319I98112
AsthmaD001249EFO_0000270J4511
LeukemiaD007938C9511
LymphomaD008223C85.911
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.011
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Critical illnessD016638112
Parkinson diseaseD010300EFO_0002508G2011
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients5353
Renal insufficiencyD051437N19112
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InflammationD007249MP_000184522
KetosisD007662R82.411
AcidosisD000138EFO_1000014E87.211
Diabetic ketoacidosisD016883EFO_100089711
Chronic renal insufficiencyD051436N1811
Kidney diseasesD007674EFO_0003086N0811
Respiratory insufficiencyD012131J96.911
Surgical wound infectionD01353011
Latent autoimmune diabetes in adultsD00007169811
Weight lossD01543111
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameInsulin human
INNinsulin icodec
Description
Recombinant human insulin
Classification
Protein
Drug class
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Identifiers
PDB1A7F, 1AI0, 1AIY, 1APH, 1AYB, 1B17, 1B18, 1B19, 1B2A, 1B2B, 1B2C, 1B2D, 1B2E, 1B2F, 1B2G, 1B9E, 1B9G, 1BEN, 1BOE, 1BOM, 1BON, 1BPH, 1BQT, 1BW5, 1BZV, 1CPH, 1DEI, 1DPH, 1E6F, 1EFE, 1EV3, 1EV6, 1EVR, 1FU2, 1FUB, 1G1F, 1G1G, 1G1H, 1G7A, 1G7B, 1GAG, 1GP0, 1GP3, 1GQB, 1GUJ, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1HIQ, 1HIS, 1HIT, 1HLS, 1HO0, 1HTV, 1HUI, 1I44, 1IGL, 1IGR, 1IMX, 1IOG, 1IOH, 1IR3, 1IRK, 1IRS, 1IZA, 1IZB, 1J73, 1JCA, 1JCO, 1JK8, 1JQH, 1K3A, 1K3M, 1KMF, 1LF8, 1LK2, 1LKQ, 1LPH, 1M5A, 1M7N, 1MHI, 1MHJ, 1MPJ, 1MSO, 1OS3, 1OS4, 1P14, 1P4O, 1PID, 1PMX, 1Q4V, 1QIY, 1QIZ, 1QJ0, 1QQG, 1RMJ, 1RQQ, 1RWE, 1SDB, 1SF1, 1SJT, 1SJU, 1T0C, 1T1K, 1T1P, 1T1Q, 1TGR, 1TRZ, 1TYL, 1TYM, 1UZ9, 1VKT, 1W8P, 1WAV, 1WDZ, 1WQJ, 1XDA, 1XGL, 1XW7, 1ZEG, 1ZEH, 1ZEI, 1ZNI, 1ZNJ, 1ZT3, 1ZT5, 2A3G, 2AIY, 2AUH, 2B4S, 2BN1, 2BN3, 2C8Q, 2C8R, 2CEU, 2CNJ, 2CQH, 2DSP, 2DSQ, 2DSR, 2E44, 2EFA, 2FHW, 2FVJ, 2G47, 2G48, 2G49, 2G4M, 2G54, 2G56, 2GF1, 2H1K, 2H67, 2H7T, 2H8B, 2HH4, 2HHO, 2HIU, 2HR7, 2INS, 2JBU, 2JG4, 2JGB, 2JGC, 2JM2, 2JMN, 2JUM, 2JUU, 2JUV, 2JV1, 2JZQ, 2K1V, 2K6T, 2K6U, 2K91, 2K9R, 2KBC, 2KJI, 2KJJ, 2KJU, 2KQP, 2KQQ, 2KVA, 2KVB, 2KXC, 2KXK, 2L1Y, 2L1Z, 2L29, 2L2A, 2L2G, 2LGB, 2LLA, 2LNH, 2LWZ, 2M1D, 2M1E, 2M2M, 2M2N, 2M2O, 2M2P, 2M68, 2M6T, 2MFR, 2MLI, 2MPG, 2MPI, 2MVC, 2MVD, 2N2V, 2N2W, 2N2X, 2N8L, 2N8M, 2OJ9, 2OLY, 2OLZ, 2OM0, 2OM1, 2OMG, 2OMH, 2OMI, 2OMP, 2OMQ, 2QIU, 2R34, 2R35, 2R36, 2RGT, 2RN5, 2TCI, 2V5N, 2V5O, 2V5P, 2VJZ, 2VK0, 2W44, 2WBY, 2WC0, 2WFU, 2WFV, 2WK3, 2WRU, 2WRV, 2WRW, 2WRX, 2WS0, 2WS1, 2WS4, 2WS6, 2WS7, 2YKT, 2YPU, 2Z8C, 2ZM3, 2ZOQ, 2ZP6, 2ZPP, 3AIY, 3BU3, 3BU5, 3BU6, 3BXQ, 3CWW, 3D94, 3E4A, 3E4Z, 3E50, 3E7Y, 3E7Z, 3EKK, 3EKN, 3ETA, 3EXX, 3F5P, 3FHP, 3FQ9, 3FQW, 3FQX, 3GF1, 3GKY, 3H44, 3HGZ, 3HK0, 3HXG, 3HXI, 3HYD, 3I3Z, 3I40, 3I81, 3ILG, 3INC, 3INS, 3IR0, 3JSD, 3KQ6, 3KR3, 3KRM, 3LRI, 3LVP, 3LW0, 3M93, 3M94, 3MMK, 3MTH, 3N56, 3N57, 3NW5, 3NW6, 3NW7, 3O23, 3OFI, 3P2X, 3P33, 3P7L, 3P7O, 3Q6E, 3QQU, 3QZ2, 3RNJ, 3ROV, 3RTO, 3T2A, 3TT8, 3TUV, 3U4N, 3U7X, 3UTQ, 3UTS, 3UTT, 3V19, 3V1G, 3W11, 3W12, 3W13, 3W7Y, 3W7Z, 3W80, 3WS3, 3ZI3, 3ZQR, 3ZS2, 3ZU1, 3ZXB, 3ZXC, 4A7E, 4AIY, 4AJX, 4AJZ, 4AK0, 4AKJ, 4BS3, 4CXL, 4CXN, 4CY7, 4D2R, 4D9T, 4D9U, 4DTT, 4DWK, 4E7T, 4E7U, 4E7V, 4EFX, 4EWW, 4EWX, 4EWZ, 4EX0, 4EX1, 4EXX, 4EY1, 4EY9, 4EYD, 4EYN, 4EYP, 4F0N, 4F0O, 4F1A, 4F1B, 4F1C, 4F1D, 4F1F, 4F1G, 4F4T, 4F4V, 4F51, 4F8F, 4FG3, 4FKA, 4GBC, 4GBI, 4GBK, 4GBL, 4GBN, 4GS8, 4GSC, 4GSF, 4I5Y, 4I5Z, 4IBM, 4IDW, 4IFH, 4IHN, 4INS, 4IOF, 4IUZ, 4IYD, 4IYF, 4J81, 4J82, 4JCJ, 4JG6, 4JG7, 4JG8, 4JS0, 4LTE, 4M1C, 4M4F, 4M4H, 4M4I, 4M4J, 4M4L, 4M4M, 4NIB, 4NUS, 4NW5, 4NW6, 4NXO, 4OGA, 4P65, 4P8Q, 4PES, 4PF7, 4PF9, 4PFC, 4PJ6, 4QIA, 4QTB, 4RAL, 4RE9, 4RXW, 4UED, 4UNE, 4UNG, 4UNH, 4WDI, 4XC4, 4XLV, 4XSS, 4XST, 4Y19, 4Y1A, 4Z76, 4Z77, 4Z78, 4Z7I, 4ZXB, 5AIY, 5AXI, 5AZZ, 5BOQ, 5BPO, 5BQQ, 5BTS, 5BXV, 5C0D, 5C97, 5CJO, 5CNY, 5CO2, 5CO6, 5CO9, 5D52, 5D53, 5D54, 5D5E, 5D9K, 5D9L, 5E1S, 5E7W, 5EKV, 5EMS, 5EN9, 5ENA, 5FB6, 5FXQ, 5FXR, 5FXS, 5HHW, 5HPR, 5HPU, 5HQI, 5HRQ, 5HYJ, 5HZN, 5IEI, 5J3H, 5JHQ, 5JYQ, 5KQV, 5L3L, 5L3M, 5L3N, 5LIS, 5MAM, 5MHD, 5MIZ, 5MJ6, 5MT3, 5MT9, 5MWQ, 5NVN, 5T7R, 5TQ1, 5U1M, 5U8Q, 5U8R, 5UDP, 5UJT, 5UOE, 5UOZ, 5UQA, 5URT, 5URU, 5USP, 5USS, 5USV, 5UU2, 5UU3, 5UU4, 5VIZ, 5WBJ, 5WBT, 5WDM, 5WOB, 5WRK, 5WRL, 5WRM, 6B3Q, 6B70, 6B7Y, 6B7Z, 6BCR, 6BCU, 6BCX, 6BCY, 6BD1, 6BD2, 6BF6, 6BF7, 6BF8, 6BF9, 6BFC, 6BLQ, 6BLR, 6BLX, 6BNT, 6BQT, 6BYZ, 6CE7, 6CE9, 6CEB, 6CK2, 6CME, 6EDS, 6F8F, 6F8G, 6FEY, 6FF3, 6FQ1, 6FQR, 6GES, 6GNQ, 6GQE, 6GV0, 6GX6, 6H3M, 6HN4, 6HN5, 6INS, 6JK8, 6JR3, 6K59, 6KH8, 6KH9, 6KHA, 6M49, 6MQ3, 6N5X, 6N5Y, 6NWV, 6O17, 6OR0, 6P4Z, 6P8I, 6PXV, 6PXW, 6PYH, 6Q8Q, 6QEY, 6QQ7, 6QQG, 6QRH, 6QRK, 6RLX, 6ROL, 6RVA, 6S34, 6S4I, 6S4J, 6SOF, 6TC2, 6TYH, 6U46, 6UM1, 6UM2, 6V02, 6VEP, 6VEQ, 6VER, 6VES, 6VET, 6VWG, 6VWH, 6VWI, 6VWJ, 6X4X, 6XC9, 6XCO, 6XCP, 6YDX, 6Z30, 6Z31, 6Z32, 6Z7W, 6Z7X, 6Z7Y, 6Z7Z, 6ZBB, 6ZEG, 6ZEI, 6ZHB, 6ZI8, 6ZIQ, 6ZIT, 6ZPO, 6ZQM, 6ZQN, 7AC4, 7AJB, 7AJC, 7AJD, 7AJE, 7AJF, 7AJG, 7AJH, 7AJI, 7AJJ, 7BW7, 7BW8, 7BWA, 7ELJ, 7ETW, 7INS, 7JP3, 7K1D, 7K1E, 7K1F, 7KD6, 7MD4, 7MD5, 7MJ6, 7MJ7, 7MJ8, 7MJ9, 7MQO, 7MQR, 7MQS, 7NHU, 7NMG, 7OPO, 7PG0, 7PG2, 7PG3, 7PG4, 7PH8, 7PHT, 7PL4, 7PPL, 7PPM, 7Q98, 7Q99, 7QAC, 7QGF, 7QHP, 7QID, 7RKD, 7RZE, 7RZF, 7RZG, 7RZH, 7RZI, 7S0Q, 7S4Y, 7S8V, 7SL1, 7SL2, 7SL3, 7SL4, 7SL6, 7SL7, 7STH, 7STI, 7STJ, 7STK, 7TYJ, 7TYK, 7TYM, 7U23, 7U6D, 7U6E, 7UFG, 7V3P, 7VKL, 7VSJ, 7WRQ, 7WSM, 7WSN, 7WW3, 7XGD, 7XLC, 7XRX, 7Y5N, 7Y5Q, 7YEW, 7YEX, 7YEY, 7YJ4, 7YK6, 7YK7, 7YQ3, 7YQ4, 7YQ5, 7YQ6, 7YRR, 7Z50, 7Z5L, 7Z5Q, 7ZYF, 8A7D, 8A7E, 8AFZ, 8AYG, 8D8O, 8DI2, 8DTL, 8DTM, 8DWN, 8EQ5, 8EYR, 8EYX, 8EYY, 8EZ0, 8GSG, 8GUY, 8HGH, 8PYI, 8PYJ, 8PYK, 8PYL, 8PYM, 8PYN, 8SBD, 9INS
CAS-ID
RxCUI
ChEMBL IDCHEMBL1201631
ChEBI ID
PubChem CID
DrugBankDB00030
UNII ID1Y17CTI5SR (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
£
Humulin Eli Lilly
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Estimated US medical usage
No data
Trends
No data
Safety
Black-box Warning
Black-box warning for: Afrezza
Adverse Events
Top Adverse Reactions
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240,751 adverse events reported
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